STUDY OF PATHOLOGY MORPHOLOGICAL CHANGES IN BABESIOS OF CARNIVORES

Abstract

Recently, there has been a trend of growth of blood-parasitic diseases among small non-productive animals, as well as expansion of the range of the vector, intermediate hosts and the causative agents of parasitic diseases. At the same time, not only carnivores can serve as a reservoir of the causative agent, but also tick populations themselves, in which the causative agent is stored due to transavarial and transfaral transmission. The share of

such animals among homeless dogs and cats is especially high. 32 Many scientists are engaged in the study of babesiosis, examining various aspects of this disease in different forms of the clinical course. However, changes in hematological indicators, in particular a significant decrease in the number of platelets in the blood, as well as hemosiderosis of the liver, have not been studied yet. The board of authors notes that hematological changes in the blood of cats with babesiosis usually manifest as regenerative hemolytic anemia in combination with poikilocytosis, polychromasia, anisocytosis, and thrombocytopenia [1]. The mechanism of thrombocytopenia has not been finally clarified. One of the possible explanations is sequestration of platelets in the spleen or immune-mediated destruction of platelets and the development of disseminated intravascular coagulopathy [2]. Biochemical changes mainly include elevated liver and kidney parameters, and sometimes elevated pancreatic enzymes and hypoglycemia. [3]. The results of hematological and biochemical studies show that in dogs with a severe form of babesiosis, erythropenia, a decrease in the level of hemoglobin, hematocrit, platelets, leukocytosis, an increase in the blood concentration of bilirubin (3.25 times), urea (1.55), creatinine (1. 23), a decrease in glucose content (by 1550%). With medium and mild severity of the disease, the above hematological and biochemical changes in dogs are less pronounced. [4, 5].