THE GENERAL MORPHO-FUNCTIONAL STATE OF THE STUDIED ORGANS WITH THE USE OF DRUGS WITH IMMUNO- CORRECTIVE AND BIOCIDAL EFFECTS DURING THE CULTIVATION OF BROILER CHICKENS

Abstract

The results of the study of drugs with immuno-corrective and biocidal effects, which can be effectively used in the conditions of poultry farming to optimize immune processes, strengthen natural resistance and immunological reactivity in order to increase the productivity and resistance of poultry to diseases, are presented. It was established that during the histological examination of the liver of the first experimental group of 40 day-old broiler chickens, minor areas of perivascular lymphoid infiltration were revealed as a result of the hepatoprotective effect. The presence of light granularity of the cytoplasm of hepatocytes may be associated with the activation of protein metabolism in the body. Complex activation of individual groups of hepatocytes, focal perivascular lymphoid infiltration, hyperplasia of the epithelium of the bile ducts characterizes a pronounced cholinergic and choleretic effect (reaction). Histological examination of the liver of the second research group of 40 day-old broiler chickens revealed activation of extramedullary hematopoiesis, which may indicate stimulation of erythropoiesis and hemoglobin formation in the bird's body. Histological examination of the liver of a control group of 40 day-old broiler chickens revealed the development of distinct microscopic changes that may be a sign of bacterial

liver damage against the background of the development of secondary bacterial infection, as well as the development of cholangitis and hepatitis. Histological examination of the heart of a control group of 40 day-old broiler chickens revealed the presence of changes indicating the development of myocardial dystrophy.Histological examination of the spleen of the first research group of 40 dayold broiler chickens revealed hyperplasia of lymphoid follicles, which is a sign of the body's immunological reactivity. Histological examination of the spleens of the control group of 40 dayold broiler chickens revealed changes that may indicate a weakening of the immune system, which was preceded by an active immune response. Usually, the detected changes are accompanied by a slow course of systemic bacterial infection of the body, which leads to a significant weakening of immunocompetent organs. The histological examination of the glandular stomach of the first research group of 40 day-old broiler chickens revealed the activation of the secretory function of the glandular apparatus, which can be characterized as a positive effect on the digestion process, because intensive primary enzymatic processing of feed contributes to the improvement of nutrient absorption processes in the intestines. The process of digestion and fermentation in the gastrointestinal tract is activated. Changes were found in the control group, which may indicate the development of proventriculitis. The detected changes may indicate the development of inflammatory processes that may occur as a result of the development of a systemic bacterial infection. Histological examination of the bursa of Fabricius of a control group of 40 day-old broiler chickens established an immunosuppressive state as a result of early exhaustion of the lymphoid organ as a result of the development of a systemic bacterial infection.Histological examination of the intestine of the first experimental group of 40 day-old broiler chickens showed hyperplasia of local lymphoid formations, which indicates immunoreactivity. A histological examination of the intestine of a control group of 40 day-old broiler chickens revealed the presence of changes that indicate the development of a sluggish